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Detailed structural orchestration of Lewy pathology in Parkinson’s disease as revealed by 3D multicolor STED microscopy

Colleagues from the department of Anatomy and Neurosciences, Amsterdam UMC – location VUmc, have recently published on post-translational modifications of alpha-synuclein (aSyn), in particular phosphorylation at Serine 129 (Ser129-p) and truncation of its C-terminus (CTT) in Parkinson’s disease (PD). Read the manuscript, with exceptional pictures, here: https://www.biorxiv.org/content/early/2018/11/14/470476