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Relationship between β-amyloid and structural network topology in decedents without dementia

Researchers from Amsterdam UMC – location VUmc published a post-mortem MRI and histology study in non-neurological controls from the Normal Aging Brain Collection (NABCA). The researchers aimed to elucidate the relationship between amyloid-β protein aggregations and network topology in decendents not meeting the pathological criteria for neurodegenerative disease (e.g. Alzheimer’s disease). The study highlights the […]

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Axonal degeneration as substrate of fractional anisotropy abnormalities in multiple sclerosis cortex

Researchers from Amsterdam UMC – location VUmc and Vita-Salute San Raffaele University in Milan have collaborated on a post-mortem MRI and histology study in multiple sclerosis (MS) and Normal Aging Brain Collection (NABCA) donors. The researchers aimed to define the histopathological substrates of diffusivity abnormalities in the cortex of MS patients and non-neurological donors. The manuscript […]

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Review on post-mortem MRI and histology studies in neurologic disease

Researchers from Amsterdam UMC – location VUmc and Leiden University, have recently written an invited review on post-mortem MRI and histology studies in multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD) and traumatic brain injury (TBI), and their relevance as radiological (bio)markers for the clinical (research) setting. The manuscript is published in Neuroscience Bulletin. Post-mortem MRI […]

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Normal Aging Brain Collection (NABCA) pipeline publication

We are proud to present the publication of our manuscript “Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls.” In open access journal Neuroimage: Clinical. We would like to thank everyone who has contributed to this publication. Click on this link to go to the manuscript. […]

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7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer’s disease.

A collaborative effort from researchers at Leiden University and Amsterdam UMC, have led to the publication of a post-mortem MRI and histology manuscript, published in Neuroimage: Clinical.  “7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer’s disease” (open access) Abstract Using 7T T2*-weighted imaging, we scanned post-mortem […]

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Structural network topology relates to tissue properties in multiple sclerosis

Researchers from the department of Anatomy and Neurosciences, Amsterdam UMC – location VUmc have combined MRI and histology to determine the the micro-scale correlates of macro-scale network measures of segregation and integration in multiple sclerosis.   https://www.ncbi.nlm.nih.gov/pubmed/30467603 OBJECTIVE: Abnormalities in segregative and integrative properties of brain networks have been observed in multiple sclerosis (MS) and are […]

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Detailed structural orchestration of Lewy pathology in Parkinson’s disease as revealed by 3D multicolor STED microscopy

Colleagues from the department of Anatomy and Neurosciences, Amsterdam UMC – location VUmc, have recently published on post-translational modifications of alpha-synuclein (aSyn), in particular phosphorylation at Serine 129 (Ser129-p) and truncation of its C-terminus (CTT) in Parkinson’s disease (PD). Read the manuscript, with exceptional pictures, here: https://www.biorxiv.org/content/early/2018/11/14/470476

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Erasmus MC – VUmc collaboration discover new gene involved in the development of Parkinson’s disease and dementia with Lewy bodies

An international team led by Prof. Vincenzo Bonifati from the Erasmus MC Rotterdam, Department of Clinical Genetics, has discovered for the first time variants in a gene (termed LRP10) in patients with familial forms of Parkinson’s disease, Parkinson’s disease and dementia, and Dementia with Lewy bodies. The paper reporting this discovery will be published in The […]