VUmc-LUMC investigators receive ‘Memorabel’ funding to unravel the pathological substrate of clinical variability in AD
Alzheimer’s disease (AD) usually and typically presents with memory disturbance. However up to 30% of AD presents with no-amnestic symptoms, especially in early onset AD. This points to a phenotypic heterogeneity that is poorly understood and rarely investigated. Recognition of variable phenotypes will lead to a better understanding of pathological pathways in AD and may have consequences for therapy and management. To identify possible underlying anatomical and neuropathological changes we will perform comprehensive post-mortem qMRI and tissue analysis of patient cohort with parietal pathological phenotype clinically validated to have a non-amnestic presentation of AD.