VUmc-LUMC investigators receive ‘Memorabel’ funding to unravel the pathological substrate of clinical variability in AD

Alzheimer’s disease (AD) usually and typically presents with memory disturbance. However up to 30% of AD presents with no-amnestic symptoms, especially in early onset AD. This points to a phenotypic heterogeneity that is poorly understood and rarely investigated. Recognition of variable phenotypes will lead to a better understanding of pathological pathways in AD and may have consequences for therapy and management. To identify possible underlying anatomical and neuropathological changes we will perform comprehensive post-mortem qMRI and tissue analysis of patient cohort with parietal pathological phenotype clinically validated to have a non-amnestic presentation of AD.

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VUmc buys LEICA TCS SP8 STED 3X super-resolution microscope

The VUmc invests in brain morphometry by buying a LEICA TCS SP8 STED 3X super-resolution microscope, nanoscope, developed by Nobel Prize laureate Stefan Hell. It allows fast, multicolour optical imaging of subcellular architecture at the nanoscale. The nanoscope will be installed in December 2014 and be available for all VUmc researchers in 2015.

Wouterlood and colleagues publish in The Journal of Neuroscience the connectivity between basal forebrain and medial prefrontal cortex in mice

In the last issue of the Journal of Neuroscience of 2014, Wouterlood and colleagues describe the basal forebrain cholinergic innervation of the medial prefrontal cortex in mice. The authors showed using stereology that there is a frontocaudal organisation of the cholinergic systems in which distinct mPFC regions are targeted depending on the location of the cholinergic neurons in the basal forebrain.

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