Mapping human brain structures and networks using post-mortem morphometrics

Image

Imaging

Post-mortem high-field qMRI datasets of the human brain are used to define and quantify anatomical structures and their networks during development and aging.

» More information
Image

Neuropathology

Extensive neuropathological assessment based on international guidelines to define lesions in the aging human brain.

» More information
Image

Stereology and morphometry

Design-based stereology and automated microscopy is used to study morphological and anatomical structures in the aging human brain.

» More information

General information

Human post-mortem brain tissue is indispensable for unravelling the pathobiological mechanisms underlying clinical and genetic phenotypes. Our aim is to establish a comprehensive collection of post-mortem neuroimaging, neuropathological and morphometry data of the aging human brain. The data and the post-mortem brain tissue will be made available for research purposes to the (inter)national research community.

We use standardized protocols for post-mortem high-field qMRI (3 and 7 Tesla MRI), including DTI, to define anatomical and pathological structures and brain networks during development, aging and disease. Stereology and automated microscopy is used to provide a 3D map of the brain structures, pathological lesions and networks.

 

All procedures of Human Brain Morphometrics comply with human rights (the right to life, liberty and security of person) and with the national legislation. Brain tissue will only be available for research anonymized.

 

Image source: Bloem, B., Schoppink, L., Rotaru, D.C., Faiz, A., Hendriks, P., Mansvelder, H.D., van de Berg, W.D.J., and Wouterlood, F.G.  Topographic mapping between basal forebrain cholinergic neurons and the medial prefrontal cortex in mice. J. Neurosci 34 (49): 16234-16246.